THE Graft Collagen

THE Graft Collagen is offered in multiple block and ring dimensions across the product line. For model numbers, dimensions (mm), and typical use contexts, see the Size Selection Guide on this page.

THE Graft Collagen is a porcine-derived collagenated bone graft block (85% hydroxyapatite, 15% Type I collagen) for filling bone defects and bone augmentation. The DPBM-C composition (85:15) provides osteoconductive properties and blood clot stability for bone formation.

THE Graft Collagen is composed of 85% hydroxyapatite and 15% Type I collagen. The hydroxyapatite is derived from porcine (pig) cancellous bone, while the Type I collagen is also of porcine origin. The hydroxyapatite component provides the structural framework, while the collagen component enhances handling properties and stability. This composition creates a bone graft material with high purity and minimal presence of organic compounds that could potentially cause immunogenicity, as all organic compounds and lipids are removed through a manufacturer's virus inactivation process.

The shelf life of THE Graft Collagen is 3 years from the date of manufacture.

In THE Graft Collagen, the weight ratio of hydroxyapatite (bone mineral) to collagen is approximately 85:15. Due to freeze-drying, moisture from the collagen evaporates, which affects the apparent weight proportion compared with moisture-containing states. A reliable volume ratio is not specified in the available product documentation.

The collagen in THE Graft Collagen is non-cross-linked collagen. It uses Type I collagen that has not undergone cross-linking processes.

Key technical characteristics and clinical use considerations of THE Graft Collagen: 1. Source: THE Graft Collagen is derived from porcine bone mineral and porcine Type I collagen. 2. Structure: As a porcine-derived DPBM-C block and ring, THE Graft Collagen is manufactured to achieve a higher-density structure. This higher bone-graft content per unit volume can support space maintenance and volume stability during healing. - Space Maintenance/Volume Stability: Higher-density graft structures may provide longer-term contour support and space maintenance; clinical outcomes depend on defect configuration, technique, and patient factors. - Wettability/Handling: When hydrated with blood or physiological saline, THE Graft Collagen maintains cohesion, helping reduce particle scattering and making it easier to precisely trim and adapt to the desired form.

While THE Graft Collagen provides better handling properties than particulate bone grafts alone, it is generally recommended to use a membrane with it for optimal results, especially in non-contained defects. For optimal bone regeneration outcomes, particularly in guided bone regeneration (GBR) procedures, using THE Graft Collagen in combination with an appropriate membrane is recommended for better space maintenance and reduced graft resorption.

The advantages of using THE Graft Collagen for maxillary sinus augmentation include optimized hydrophilic properties. THE Graft Collagen ensures reliable and uniform hydration, which may support procedural preparation efficiency during sinus lift procedures. ※ Results may vary depending on individual patient conditions

THE Graft and THE Graft Collagen differ in composition and handling profile. Clinical application: THE Graft is used for filling various defects and requires a membrane for containment, while THE Graft Collagen is often selected for shaped defects and is easier to place and maintain position.

Common indications described for THE Graft Collagen include: 1. Socket preservation and ridge preservation procedures - Particularly effective for maintaining alveolar ridge dimensions after tooth extraction - Available in block and ring types to fit different socket shapes and sizes 2. Intra-socket bone grafting - Used for filling extraction sockets while maintaining space 3. Ridge augmentation procedures - The moldable nature makes it ideal for adapting to ridge contours 4. Layering technique applications - Can be effectively combined with THE Graft in layered approaches 5. Periodontal intrabony defects - The collagen component helps with stability in these contained defects 6. Gap filling during immediate implant placement - Maintains position better than granular materials alone 7. Peri-implantitis dehiscence defects - The ring type is particularly useful for treating these defects THE Graft Collagen is often discussed for contained defects where its handling properties, moldability, and volume maintenance capabilities provide significant advantages over traditional granular materials. ※ Results may vary depending on individual patient conditions

Tips for using THE Graft Collagen: 1. Hydration technique: - Can be used in original condition or hydrated with saline or blood - Molding is often easier after hydration 2. Shaping and adaptation: - Use sterile scissors or blades to trim the block to the desired shape before placement - Avoid excessive pressure when molding to preserve the porous framework 3. Layering approach: - Layering approaches vary by defect morphology and clinician preference; if combining particulate graft and a collagenated block/ring, adapt materials to maintain space and contour, following IFU and case-specific planning 4. Membrane coverage: - Cover with an appropriate barrier membrane when indicated - Both resorbable and non-resorbable membranes may be used depending on the case 5. Placement considerations: - Avoid overfilling the defect site - Ensure good adaptation to defect walls for stable positioning 6. Storage: - Store at temperatures between 15°C-25°C (59°F-77°F) - Keep away from direct sunlight 7. Handling: - Always use sterile surgical instruments and gloves when handling the material - THE Graft Collagen is for single use only - never reuse or re-sterilize

Based on the cited summaries, reported dimensional or volumetric changes may occur over time as healing and remodeling progress. The collagen component (described in some materials as approximately 14-17% of the initial volume) is expected to resorb over time. Treatment planning should follow IFU indications and clinician judgment; outcomes vary by defect type, technique, and patient factors. Paper: "Particulate Versus Cross-Linked Collagenated Bone Substitutes for Guided Bone Regeneration: A Randomized Controlled Trial" (see listed references for DOI and details). ※ Results may vary depending on individual patient conditions

THE Graft Collagen is difficult to visualize on X-rays due to its high porosity. While this makes it less visible radiographically initially, the porous structure creates space for bone cell attachment and new bone formation under stated conditions. As healing progresses, the grafted area may gradually show increased radiopacity on follow-up imaging.

THE Graft Collagen may be molded and adapted to fit the defect morphology. Regarding pressure: available documentation does not specify a single numeric pressure value. In practice, clinicians typically use light manual pressure to adapt the block/ring while avoiding excessive compression that could collapse the porous framework. Final handling technique should follow IFU guidance, defect configuration, and clinician judgment.

Moistening with saline makes it easier to cut into pieces and shape appropriately. THE Graft Collagen can also be hydrated with blood per IFU and case preference.

THE Graft Collagen has a reported short hydration time. Manufacturer and study summaries for this line report full hydration within seconds under described test conditions; clinical chairside may vary on the procedure and model.

THE Graft Collagen shows the following remodeling timeline in cited summaries: Significant bone formation is described as beginning at around 4-5 months, with further maturation commonly discussed at later follow-up (e.g., 5-6 months). Remodeling is generally discussed over approximately 1 year, with variation depending on defect type, technique, and patient factors. Some cited summaries describe cortical line formation becoming visible within the first year. In histological analyses at various time points, new bone formation surrounding residual graft material has been described. Treatment planning and timing should follow IFU indications and clinician judgment. ※ Results may vary depending on individual patient conditions

Peer-reviewed studies involving THE Graft Collagen are listed with full citations and DOIs in the Clinical Evidence and Reference (Academic Evidence) sections on this page (#clinical-evidence).

Effect on bone quality: Although there are concerns that a large amount of collagen in bone grafts may degrade bone quality, bone graft materials containing an appropriate amount of collagen help maintain stable volume and promote vascularization during bone formation. Effects on remodeling process: Collagen in bone blocks can enhance guided bone regeneration. Collagen stabilizes the blood clot, maintaining a high concentration of autogenous growth factors. Collagen promotes osteoconductivity, increasing the percentage of new bone formation and reducing residual grafting material. Practical handling characteristics discussed in clinical reports despite potential quality concerns: Collagen-containing materials offer better handling properties and stability. They show high hydrophilicity due to their high surface area and porosity. They promote hemostasis and angiogenesis, and induce cell migration necessary for regeneration. ※ Results may vary depending on individual patient conditions

Yes, THE Graft Collagen can be used with screws and pins: 1. Clinical cases demonstrate the combined use of THE Graft Collagen with: - Bone tacks for stabilization in GBR procedures - Tenting screws in guided bone regeneration techniques 2. The combination provides several benefits: - Improved stability of the graft material during healing - Better space maintenance for bone regeneration - Enhanced predictability of the bone augmentation procedure 3.Specific techniques documented in clinical cases: - "Tenting screw with implant simulation" technique using THE Graft Collagen - Immediate implant placement with bone graft stabilized by tacks 4. Surgical protocols often include: - Placement of tenting screws or pins first - Application of THE Graft Collagen around the hardware - Coverage with a resorbable or non-resorbable membrane - Stabilization with additional tacks if needed This combination approach helps maintain the volume of the augmented site and prevents collapse of the overlying membrane, leading to more predictable bone regeneration outcomes. ※ Results may vary depending on individual patient conditions

THE Graft Collagen blocks can be trimmed with sterile surgical scissors or a scalpel to the desired shape. Trim while dry for more precise cutting, or hydrate first in saline for 1-2 minutes for easier shaping. Shape the block to match defect contours; for irregular defects, smaller pieces may be packed together. After placement, the trimmed block can be further adapted in situ using light pressure.

THE Graft Collagen Ring Type is offered in sizes including 5x3x8mm, 5x4x9mm, and 5x5x10mm (Height x Inner Ø x Outer Ø). It is used for socket preservation, ridge preservation, and peri-implantitis defects by placing the ring into the extraction socket, over a ridge defect, or around an exposed implant surface to maintain space during healing.

Collagen is added to bone graft materials for the following reasons: 1. Improved handling properties: - Enhances manipulation and placement during surgery - Allows the material to be easily shaped to fit bone defects - Provides better stability and pressure transmission 2. Biological benefits: -Promotes hemostasis and angiogenesis due to high hydrophilicity - Induces cell migration necessary for regeneration - Stabilizes blood clots, maintaining high concentration of autogenous growth factors - Promotes osteoconductivity, increasing percentage of new bone formation 3. Structural advantages: - Creates a composite material that mimics natural bone matrix - Maintains space for blood vessel formation through trabeculae structure - Provides resistance to degradation while allowing controlled resorption 4. Clinical performance: - Increases bone quantity in sites with insufficient bone for implants - Induces bone formation in defect areas - Facilitates handling during surgery while maintaining volume after surgery - Collagen-containing bone grafts are described as offering handling advantages in terms of manipulation and stability, making them particularly useful for bone augmentation procedures.

Type I collagen is used in THE Graft Collagen bone graft material. Specifically: 1. Source: - THE Graft Collagen incorporates Type I collagen derived from porcine tendon 2. Verification methods: - The Type I collagen is verified through SDS-PAGE analysis - Amino acid analysis confirms it as Type I collagen by detecting: - High mol% of hydroxyproline - Minimal amounts of tyrosine, tryptophan, and cysteine 3. Quality control: - Amino acid analysis is performed for every lot of THE Graft Collagen - This ensures consistency and high quality by verifying the collagen type 4. Safety features: - The Type I collagen undergoes virus inactivation processes - It is processed to remove terminal telopeptides that could induce antigenicity and immunogenicity - The collagen is processed into atelocollagen form by enzyme treatment of N-terminal and C-terminal regions Type I collagen is specifically chosen because it is the predominant collagen type in bone tissue, providing structural support while maintaining biocompatibility.

The collagen in THE Graft Collagen is derived from porcine (pig) sources. Specifically: 1. Source details: - The Type I collagen is extracted from porcine tendon - The porcine raw materials originate from Korea and Australia 2. Advantages of porcine-derived collagen: - Porcine bones and tendons have a relatively low risk of zoonosis compared to bovine sources - Porcine-derived materials are free from the risk of Creutzfeldt-Jakob Disease - The crystalline and morphological structures of porcine bone resemble human cancellous bone - Porcine bone's porosity structure and form are more similar to human bone, providing better biocompatibility 3. Safety considerations: - Porcine materials, unlike bovine bone and cattle ligaments, don't require management of TSE (Transmissible Spongiform Encephalopathy) agents - Raw materials undergo safe practices adhering to regulatory standards (HACCP, GMP) - The collagen is processed through virus inactivation to eliminate infection risk Regulatory status: - THE Graft Collagen with porcine-derived collagen is approved for use in 10 countries including Korea and EU nations - It was the first application of MDR (Medical Device Regulation) with THE Graft in Korea as a xenograft for EU The choice of porcine sources represents a strategic decision to maximize biocompatibility while minimizing potential risks associated with other animal-derived materials.

THE Graft Collagen may be listed as a biomaterial for tissue repair or bone graft material under Korean national health insurance when use aligns with approved indications and current HIRA/EDI schedules. Whether a specific case is reimbursable depends on the diagnosis, procedure, and billing rules at the time of treatment. In accordance with HIRA standards, reimbursement is generally considered only when use matches approved diagnostic codes, such as bone defects related to osseous lesions or certain periodontal regenerative indications. Bone grafting performed solely for routine implant placement is often classified as non-reimbursable. Clinics should confirm the applicable EDI code and listing status for the specific THE Graft Collagen model in the hospital billing system (OCS/EMR) against the latest official schedules. Use should follow the instructions for use and locally approved labeling.

THE Graft Collagen is used internationally in multiple markets: 1. Market presence: - THE Graft Collagen is sold in 10 countries including Korea and European Union member states 2. Regulatory achievements: - The product has achieved MDR (Medical Device Regulation) approval for the European market - It was noted as "the first application of MDR with THE Graft in Korea as a xenograft (EU)" 3. International clinical applications: - Clinical cases and studies from different countries demonstrate its use in various dental procedures including: - Socket preservation - Ridge preservation - Peri-implantitis dehiscence defect treatment While the search results confirm international usage across multiple countries, they don't provide specific market share data or comparative usage statistics between countries. The regulatory approval in the EU market suggests compliance with international standards and acceptance in developed healthcare markets. Use should follow the instructions for use and locally approved labeling.

THE Graft Collagen is used in multiple Korean dental university hospitals and has been featured in various academic research papers. (*This information does not guarantee the efficacy or effects of the product. Specific use should follow the instructions for use and the clinical judgment of a qualified professional.)

THE Graft Collagen is manufactured using optimized process, resulting in a high density and tightly combined bone graft material; consequently, it offers volume retention and maximizes clinical predictability.

the Ring Type of THE Graft Collagen appears to have been developed for specific clinical applications: 1. Implant placement: - The Ring Type is designed to facilitate simultaneous implant placement and bone grafting - It allows for immediate implant placement while providing bone augmentation around the implant 2. Defect-specific design: - The Ring Type is particularly useful for treating specific defect configurations - It provides better adaptation to certain types of bone defects, especially those with vertical dimension needs 3. Available in multiple sizes: - TCR-01: 5x3x8 mm - TCR-02: 5x4x9 mm - TCR-03: 5x5x10 mm - These varying dimensions allow for selection based on the specific defect size and implant diameter 4. Clinical applications: - Used in ridge preservation procedures - Particularly effective in cases with buccal bone deficiency - Provides a structural framework for bone regeneration while allowing implant placement The Ring Type appears to be designed to address the specific clinical need for simultaneous implant placement and bone augmentation, offering a convenient solution that maintains space and provides structural support during healing.

Yes, THE Graft Collagen is suitable for socket preservation procedures. here's how it can be properly used: Application Methods: 1. Single Use Method: - THE Graft Collagen can be used alone to fill the extraction socket - The material should be compactly filled into the extraction socket - After filling, cover with a resorbable collagen membrane - Secure with interrupted and horizontal mattress sutures (4-0 e-PTFE Biotex® recommended) 2. Layering Technique: - Place THE Graft (particulate form) at the bottom of the socket - Place THE Graft Collagen on top - This combination technique may provide better bone quality according to some clinicians Histological Analysis: - Histological evaluation 6 months after socket preservation showed residual bone material surrounded by new bone, indicating successful biochemical fusion Benefits for Socket Preservation: - High porosity promotes effective new bone formation - Favorable packing ability and pressure transmission - Hydrates easily for precise control over graft material - High stability and bone regeneration efficiency THE Graft Collagen is particularly useful for socket preservation due to its handling properties and ability to maintain the extraction socket volume while promoting bone regeneration.

Yes, THE Graft Collagen is suitable for alveolar ridge preservation. here's how it can be properly used: Application Methods: 1. Standard Technique: - Compactly fill THE Graft Collagen into the extraction socket - Cover with a resorbable collagen membrane - Secure with interrupted and horizontal mattress sutures 2. L-Technique: - Shape THE Graft Collagen in an L-configuration to match the defect - Apply membrane over the graft material - Fix the membrane using sutures - This technique is particularly useful for ridge preservation in posterior areas 3. Layering Technique: - Place THE Graft (particulate form) as the base layer - Add THE Graft Collagen (ring type) on top - Use an open barrier membrane technique - This combination may provide better bone quality according to clinical experience Clinical Case Examples: Effectiveness: - THE Graft Collagen has been used successfully in both intact and damaged extraction sockets - Histological analysis shows residual bone material surrounded by new bone, indicating biochemical fusion - Studies demonstrate effective ridge preservation with minimal dimensional changes THE Graft Collagen is particularly effective for ridge preservation due to its handling properties, volume stability, and ability to promote bone regeneration while maintaining the alveolar ridge dimensions. Use should follow the instructions for use and locally approved labeling.

Although THE Graft Collagen provides better handling properties than particulate bone grafts alone, the use of a membrane is generally recommended for optimal results. 1. Documented cases: A resorbable collagen membrane is used in conjunction with THE Graft Collagen for socket preservation. 2. Clinical evidence: In non-contained defects, using THE Graft Collagen without a membrane may lead to greater ridge dimension loss, so membrane coverage is recommended. 3. Membrane functions: - Maintains space and stabilizes the graft material. - Prevents the graft from dispersing. - Enhances bone regeneration outcomes. 4. Intact periosteum considerations: - While some literature suggests intact periosteum may provide similar effects to resorbable membranes, clinical experience indicates that periosteum alone cannot provide the same space maintenance and graft stabilization that membranes offer. 5. Exception: - If the bone defect has a shape that naturally prevents graft material dispersion, membrane use might be less critical. In conclusion, while THE Graft Collagen has favorable handling characteristics compared to particulate grafts, using a membrane is still recommended for optimal outcomes in socket preservation, particularly in non-contained defects where graft stability is needed. Use should follow the instructions for use and locally approved labeling.

Yes, THE Graft Collagen is suitable for both horizontal and vertical bone augmentation procedures. Here's how it should be properly used: For Horizontal Bone Augmentation: 1. Application Methods: - Use THE Graft Collagen in block form - Trim the block to an L-shape to fit the defect area - Cover with a collagen membrane , a resorbable collagen membrane or THE Cover) - Secure primary closure using retentive flap technique 2. Clinical Outcomes: - THE Graft Collagen provides good handling properties and stability for horizontal augmentation For Vertical Bone Augmentation: 1. Application Methods: - Mix with autogenous bone when possible for better outcomes - Use titanium-reinforced membranes (like OpenTex-TR) or titanium mesh for space maintenance - Consider using THE Graft Collagen with THE Graft particulate for better stability 2. Important Considerations: - Vertical augmentation is most predictable up to 3mm from the host bone - When using only bone substitutes without autogenous bone, longer healing periods (10+ months) are recommended - For vertical augmentation beyond 3mm, consider mixing with autogenous bone or growth factors , rhBMP-2) - Adequate space maintenance using titanium-reinforced membranes is crucial THE Graft Collagen offers advantages for both horizontal and vertical bone augmentation, including improved handling, shape stability, and space maintenance compared to particulate grafts alone. However, technique-sensitive procedures like vertical augmentation require careful planning and execution for predictable outcomes.

Yes, THE Graft Collagen is suitable for maxillary sinus bone grafting procedures. here's how it can be properly used: Application Methods: 1. Lateral Window Approach: - Create a lateral window to access the sinus cavity - Carefully elevate the sinus membrane - Apply THE Graft Collagen (collagenated block bone substitute) to the elevated sinus - Place a resorbable collagen membrane over the lateral window - Suture the site appropriately 2. Crestal Approach: - Can be used with osteotome sinus floor elevation techniques - Both simple techniques and bone-added osteotome sinus floor elevation (BAOSFE) techniques are viable - In cases with residual bone height of 5mm or less, bone grafting is recommended 3. Implant Placement Timing: - Can be used for both simultaneous implant placement and staged approaches - For simultaneous placement, ensure primary stability of the implant Clinical Evidence: - Studies show successful bone formation and osseointegration when using THE Graft Collagen in sinus augmentation procedures - Comparative studies with bovine-derived materials show similar clinical outcomes - THE Graft Collagen has been used successfully in various sinus augmentation techniques, including lateral window and crestal approaches Advantages for Sinus Grafting: - The collagen component provides better handling properties - Maintains volume stability in the sinus cavity - Can be easily shaped to fit the sinus cavity - Hydrates easily for precise control over the amount of graft material - High stability and bone regeneration efficiency THE Graft Collagen is an effective option for maxillary sinus bone grafting procedures, offering good handling properties, volume stability, and successful clinical outcomes when used according to proper surgical protocols. Use should follow the instructions for use and locally approved labeling.

Based on clinical studies, THE Graft Collagen shows limited effectiveness in 1-wall defects compared to 2-wall and 3-wall defects. Volume stability was poorer compared to multi-wall defects due to fewer surrounding walls providing support for the graft material. Therefore, if guided properly using a membrane, sufficient volume is maintained even in a 1-wall defect, and ossification occurs effectively. Use should follow the instructions for use and locally approved labeling.

The collagen contained in THE Graft Collagen is completely absorbed within one month after implantation. Thereafter, the remaining THE Graft acts as a scaffold, influencing new bone formation and bone remodeling. Bone remodeling generally takes about 1 year, with significant variation depending on graft material type. THE Graft shows reported with shorter timing in some cited summaries remodeling, with cortical line formation visible within 1 year, which may indicate earlier new bone formation in cited summaries. For long-term stability specifically, the available data suggests xenograft materials persist in the body longer than autografts or allografts, providing structural support while natural bone forms around them.

Non-resorbable membranes are generally preferred for extensive defects like 1-wall defects because they provide better space maintenance and structural support When using THE Graft Collagen in wide defect areas, non-resorbable membranes or mesh are recommended to prevent membrane exposure and ensure better outcomes Clinical experiences indicate that non-resorbable membranes are more effective for horizontal bone augmentation in large defects, though they carry a risk of exposure For cases with significant buccal bone recession, collagen membranes are recommended over collagen matrix materials to provide better stability for the bone graft

THE Graft Collagen Product Line Overview in this size is recommended for dental bone defect management in guided regenerative workflows. This size-focused allocation helps reduce material waste and supports precise graft adaptation to the defect boundary.

Compared with particulate grafts, this collagenated block format is designed for improved handling cohesion and space maintenance at the recipient site. For reported hydration time under described test conditions, see the hydration time FAQ on this page (#faq).